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KMID : 0359320080480030385
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Korean Journal of Veterinary Research
2008 Volume.48 No. 3 p.385 ~ p.391
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Effects of 2,3`,4,4`,5-pentachlorobiphenyl (PCB#118) on morphological changes in the rat testis
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Kim Gon-Sup
Park Oh-Sung
Han Dae-Yong
Kim Mun-Ki
Koh Phil-Ok
Cho Jae-Hyeon
Kim Soon-Bok
Won Chung-Kil
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Abstract
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This study was performed to examine the effect of 2,3`,4,4`,5-pentachlorobiphenyl (PCB#118) on testis of male rats. PCB#118 (20 mg/kg/week) in corn oil was intraperitoneally injected to adult male rats for 2, 5, 8 weeks. The body and testicular weights were measured at 3, 6, 9 weeks of PCB treatment. The morphological changes in the rat testes were then analyzed by light microscopy (LM) and transmission electron microscopy (TEM). The results showed that PCB#118 caused significant change in the body weights and testicular weights. Moreover, the morphological studies that were conducted on the PCB-treated rats revealed that the number of spermatocytes and spermatids in their seminiferous tubules decreased than control group (LM). The nuclear membrane was damaged when PCB was administered to them for 9 weeks (TEM). These results suggest that the reproductive function of the adult male rats is sensitive to PCB#118, and that may affect the testicular morphology of adult male rats.
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KEYWORD
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morphology, polychlorinated biphenyl, testis
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